Diagnostic Test Of Frozen Section Histopathological Preparations Against Gold Standard Histopathology Of Paraffin Block In Breast Tumor

Abstract

When it comes to examining the anatomical pathology of breast tumors, paraffin block histopathology is the gold
standard. This examination has the disadvantage of taking a long time. One of the examinations that can diagnose
breast tumors quickly is frozen section histopathological examinations which is often used by clinicians as a guide
during surgery. In order to evaluate an examination, a diagnostic test used by comparing the results with a gold
standard. This study aims to compare frozen section histopathology results with the gold standard paraffin blocks.
In this study, secondary data from medical records of patients with breast tumors who underwent frozen section
histopathology and paraffin block histopathology examination is used to describe the findings of the research. A
2x2 cross tabulation was used to analyze the data for sensitivity, specificity, positive predictive value (PPV) and
negative predictive value (NPV) in comparison with paraffin block histopathology, the gold standard in
histopathology. The results of frozen section diagnostic test are sensitivity is 85.71 percent, specificity is 100
percent, positive predictive value (PPV) is 100 percent, negative predictive value (NPV) is 66.67 percent, and
accuracy is 88.89 percent. Frozen section histopathology has good diagnostic value and can be used to diagnose
breast tumors well.