HISTOPATHOLOGICAL DESCRIPTION OF THE LUNGS OF MICE (MUSMUSCULUS) THAT WAS GIVEN ASCORBIC ACID

Abstract

Ascorbic acid or better known strengthening immunity against infection, especially during thecurrent covid 19 outbreak, the people's consumption power of ascorbic acid is extraordinary. Thelung is an elastic cone-shaped organ located in the thoracic cavity and is an organ that oftenexperiences pathological abnormalities. An imbalance of oxidants– antioxidants are mutuallyreinforcing and contribute to tissue damage. The purpose of this study was to determine theeffect of consuming low doses of ascorbic acidevery day on lung histopathology, especiallyfibrosis in mice (Mus musculus). This study was an experimental study with post-test only with acontrol design and used 15 mice as samples. Samples were divided into 5 groups consisting of onepositive control group, one negative control group and three different dose groups from theascorbic acid treatment group (0,76mg,0,51 mgdan 0,26 mg in one treatment, here is done 2timesthetreatmentinonedayfor7days).Dataanalysismatchresultstothescoretabledetermining the damage in the form fibrosis. The histological structure of the lungs mice fromeach treatment compared to the control. The damage score of each tweet then per group issummed up and averaged. Furthermore, data analysis is carried out using the One Way ANOVAtest.. In conclusion, study was conducted consumption of ascorbic acid below the dose alsoresulted in damage to the pulmonary organs and the result is the same as not consuming ascorbicacid