Description of Liver Function on the Effect of Treatment on Pulmonary Tuberculosis Patients at the Manado City Health Center

Abstract

Tuberculosis (TB) is caused by Mycobacterium tuberculosis. This bacterium usually attacks
the lungs, but TB bacteria can also attack other parts of the body such as the kidneys, spine,
and brain. Anti Tuberculosis Drugs (OAT) is the most important component in TB treatment.
TB treatment is one of the most efficient efforts to prevent the further spread of TB. Research
conducted by Ashford et al (2015), the risk of hepatotoxicity in the use of first-line OAT
increases at the age of 60 years. Also a study conducted byPrihatni et al (2005) as many as
62.5% of subjects who used hepatotoxic Rifampicin in the second week after treatment, this
study also showed an increase in serum ALT (alanine aminotransferase) due to the
combination of OAT with rifampicin. The purpose of this study was to determine the
description of liver function on the effects of treatment for pulmonary TB patients at three
health centers in Manado city.
Thirty pulmonary TB patients at the Ranotana Weru, Tuminting and Tikala Health Centers
were interviewed and their blood samples taken for examination of AST, ALT and bilirubin
levels in the laboratory. The results showed that the ALT/SGPT enzyme activity value in
patients with pulmonary tuberculosis in the normal range was 10-29 U/L in 24 (80%) patients
and the abnormal value was 34-82 U/L in 6 (20%) patients. The value of AST/SGOT enzyme
activity in patients with pulmonary tuberculosis in the normal range was 12-30 U/L in 25
(83.4%) patients and an abnormal value of 33-100 U/L, in 5 (16.6%) patients. Bilirubin levels
in all pulmonary TB patients within normal limits are 0.22 – 1.30 mg/dl. Undesirable effects
that arise during the treatment of pulmonary tuberculosis are itching and redness of the skin,
joint pain, tingling and burning in the legs, red urine and sweat, nausea and vomiting.
Suggestion, for health workers can provide health education to patients and their families
monitoring OAT about the conditions and effects related to the dose of the drug given, the
patient's family as OAT monitors must be able to ensure that patients with pulmonary
tuberculosis who are in the treatment stage are obedient to taking medication and seek to
recognize their condition. or signs and symptoms complained of due to the effects of the drug
by the patient